منابع مشابه
Mantle Cell Lymphoma with Multiple Lymphomatous Polyposis Presenting With Intussusceptions
Mantle cell lymphoma is an aggressive type of B-cell non-Hodgkin's lymphoma that originates from small to medium sized lymphocytes located in the mantle zone of the lymph node. The gastrointestinal tract is the predominant site of extranodal involvement in the form of multiple lymphomatous polyposis. Multiple lymphomatous polyposis due to mantle cell lymphoma presenting with intussusception is ...
متن کاملCurrent treatment standards and emerging strategies in mantle cell lymphoma.
Mantle cell lymphoma (MCL) is a unique subtype of B-cell non-Hodgkin lymphomas characterized by the chromosomal translocation t(11;14)(q13;q32) and nuclear cyclin D1 overexpression in the vast majority of cases. Most patients present with advanced stage disease, often with extranodal dissemination, and pursue an aggressive clinical course in the majority of cases. Recent improvement has been ac...
متن کاملCurrent and emerging therapies in mantle cell lymphoma.
Mantle Cell Lymphoma, characterized by the t(11;14)(q13; q32) chromosomal translocation and cyclin D1 expression, remains one of the most challenging lymphoma subtypes to treat. Therapy can be divided into treatment modalities for younger, stem cell transplant (SCT)-eligible patients vs older, SCT-ineligible patients. For clinically fit patients younger than 60-65 years of age we recommend cyta...
متن کاملCurrent treatment standards and future strategies in mantle cell lymphoma.
The genetic hallmark of mantle cell lymphoma (MCL) is the translocation t(11;14)(q13;q32), which can be detected by classical cytogenetics or FISH analysis resulting in overexpression of the cell cycle regulator protein cyclin D1, which may be detected by immunostaining in the large majority of cases. It is still under debate whether cases of atypical CLL with t(11;14) represent a different dis...
متن کاملThe current therapeutic scenario for relapsed mantle cell lymphoma.
PURPOSE OF REVIEW Patients with relapsing mantle cell lymphoma (MCL) still represent a demanding challenge for the hematooncologist. The dismal prognosis and the absence of generally accepted therapeutic standards hamper the clinical management of such cases. Moreover, the availability of many targeted approaches, in a field so far missing efficient salvage regimens, challenges current therapeu...
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ژورنال
عنوان ژورنال: Journal of Hematology & Thromboembolic Diseases
سال: 2015
ISSN: 2329-8790
DOI: 10.4172/2329-8790.1000215